Search results for " PERK"
showing 6 items of 6 documents
Ureteru akmeņu endoskopiskās ārstēšanas iespējas
2016
Ievads: Urīnakmeņu incidence pasaulē ir 1500-2000 gadījumi uz miljonu iedzīvotāju. Pēc statistikas datiem nierakmeņu izplatības rādītāji svārstās no 1% līdz 20%. Šī slimība ir novērojama pacientiem pārsvarā no 30 līdz 50 gadu vecumā. Pēc Eiropas Urologu asociācijas 2012. gada datiem nierakmeņu slimību sastop aptuveni 20% gadījumu no visām uroloģiskajām saslimšanām. Materiāli un metodes: Retrospektīvā pētījumā tika iekļauti 123 pacienti ar urolitiāzi, kuri ārstējās Paula Stradiņa klīniskā universitātes slimnīcā 4. uroloģijas nodaļā laika posmā no 2013. gada 1. janvāra līdz 2014. gada 31. decembrim. Tiek ievākti un analizēti sekojošie pacientu dati: pētījumu objekta skaits; vecums un to dzimu…
EVALUATION OF OOCYTE QUALITY IN GRANULOSA AND CUMULUS CELLS OF PATIENTS UNDERGOING PMA
2019
Background. We investigate the apoptosis rate of individual granulosa cell–oocyte and cumulus cell–oocyte (COC), associated with the levels of molecules playing a critical role in the regulation of cell death or survival. These molecular analyses have been done to verify the difference of competence between oocytes producing embryos able to reach the blastocyst stage compared with embryos arrested during the in vitro culture. Methods. From each single follicle: granulosa cells were processed for Western blotting analyses, using the following antibodies: pAKT, ERK 1/2, pERK 1/2; cumulus cells were used for in situ immunofluorescence with the same antibodies. DNA fragmentation rate was measur…
UNRAVELLING THE ROLES OF THE NUCLEAR PROTEIN 1 DURING ER-STRESS INDUCTION
2020
Background: NUPR1 was described as a transcriptional factor involved in the regulation of various cellular stress-response genes, playing a crucial role in the condition of the endoplasmic-reticulum (ER) stress, thus emerging as a common molecular factor of different pathologies, obesity, hepatic steatosis, and cancer. In the present work we aim to explore how NUPR1 interacts with some pivotal genes that are the major modulators of the ER stress and metabolic cell functions. In particular we investigated the biochemical and molecular effects arising from the loss of NUPR1 in ER stress physiological conditions. Methods: We used prolonged high fat diet (HFD) feeding to induce ER stress physio…
Looking for Feminist Pragmatist Roots of Degrowth Ideas: Jane Addams, Charlotte Perkins Gilman, Caroline Bartlett Crane
2022
The aim of the paper is a search of feminist pragmatist roots of degrowth ideas. The starting point is the question of whether in views of the members of the Progressive Movement the idea of progress has always implied the economic (and industrial) growth. Searching for counter-examples leads me to ideas of ecofeminism and feminist critics of capitalism in the previous turn of the centuries. The ideas of ecofeminism were developed by women associated with the Department of Sociology at the University of Chicago and the social settlement Hull House. They observed a link between the exploitation of subordinate members of a society and the degradation of nature in Western cultural values. The …
Marcella Romeo, Charlotte Perkins Gilman. Racconti di silenzi e di anarchie, Quattrosoli, Palermo 2008
2009
Monthly Bonaire coral Sr/Ca and oxygen isotope data from 118 kyr ago (coral BON-5-D)
2015
The end of the last interglacial period, ~118 kyr ago, was characterized by substantial ocean circulation and climate perturbations resulting from instabilities of polar ice sheets. These perturbations are crucial for a better understanding of future climate change. The seasonal temperature changes of the tropical ocean, however, which play an important role in seasonal climate extremes such as hurricanes, floods and droughts at the present day, are not well known for this period that led into the last glacial. Here we present a monthly resolved snapshot of reconstructed sea surface temperature in the tropical North Atlantic Ocean for 117.7±0.8 kyr ago, using coral Sr/Ca and d18O records. W…